Get Applications of Biotechnology in Neurology PDF

By Kewal K. Jain

ISBN-10: 1627032711

ISBN-13: 9781627032711

ISBN-10: 162703272X

ISBN-13: 9781627032728

Culling jointly excerpts from a variety of writings by way of Dr. Kewal okay. Jain on biotechnology issues as they relate to problems of the frightened approach, Applications of Biotechnology in Neurology covers a number of functions for these operating in existence sciences and the pharmaceutical sciences, relatively these constructing diagnostics and therapeutics for the frightened procedure. This exact quantity delves into components reminiscent of neurobiotechnology, like neurogenomics and neuroproteomics, molecular diagnostics, a number of tools of bettering systemic management of gear for particular supply to the frightened procedure, together with using nanobiotechnology, biotechnology-based thoughts and items for neuroprotection, in addition to chapters on neurosurgery and custom-made neurology.

Thorough, state of the art, and thoughtfully equipped, Applications of Biotechnology in Neurology serves as an excellent advisor, supplemented through seventy five tables and sixteen figures in addition to various references from fresh literature in this subject, that are appended to every chapter.

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Extra resources for Applications of Biotechnology in Neurology

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Creation of Transgenic Models of Neurologic Disorders Animal models of human neurologic disease are assuming an important role in evaluation of various new treatments, including gene therapy. Spontaneously occurring genetic defects in animals are inadequate for serving as models of human disease, thus, the need for induced mutations. Mutations can be established in the animal genome by one of two approaches: nonhomologous recombinations (transgenic) or homologous recombinations (knock-out, null mutations).

The focus of this report is DNA sequencing. RNA is rather unstable in the cell, but as it is generated by transcription from DNA, the information is already present in the cell’s DNA. However, it is sometimes desirable to sequence RNA molecules. To sequence RNA, the usual method is to reverse transcribe the sample first to generate DNA fragments, which can then be sequenced. Technologies for DNA sequencing are described in detail elsewhere (Jain 2012). DNA Libraries There are two main types of DNA libraries: genomic and cDNA.

Viral DNA-dependent RNA polymerase. Nature 1970:226:1209–1211. Blaese RM, Culver KW, Anderson WF. The ADA human gene therapy protocol. Human Gene Therapy 1990;1:331–62. Crow JF. Sixty years ago: the 1932 International Congress of Genetics. Genetics 1992;131:761–8. Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998;391:806–11. Freitas RA Jr. Exploratory design in medical nanotechnology: a mechanical artificial red cell.

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Applications of Biotechnology in Neurology by Kewal K. Jain

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