By Hans-Georg Kräusslich, Ralf Bartenschlager
A an important factor for antiviral remedy is the truth that all antiviral elements swiftly pick out for resistance; hence, tracking and overcoming resistance has develop into a most vital scientific paradigm of antiviral treatment. This demands wary use of antiviral medicines and implementation of mix treatments. In parallel, efforts in drug discovery must be persevered to enhance compounds with novel mode-of-action and job opposed to resistant traces. This ebook experiences the present prestige of antiviral remedy, from the roads to improvement of latest compounds to their scientific use and value effectiveness. person chapters deal with in additional aspect all to be had drug sessions and description new techniques presently lower than development.
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Additional resources for Antiviral strategies
2006; Koch and Narjes 2006; Meanwell et al. 2005; Neyts 2006; Shim et al. 2006; Wu et al. 2005), which summarize the development of agents to treat HCV infection. In this report we highlight the application of modern drug discovery tools and techniques to inhibit HCV replication by describing selected examples that have appeared recently in the scientific literature. As illustrated in Scheme 1, antiviral discovery begins with drugs that may be used as probes of biological function. The structure-based analysis and modeling described in the next two subsections can provide a context for understanding the molecular patterns responsible for a drug’s action at its receptor.
NS5B is the key enzyme responsible for the synthesis of negative strand RNA, using the genome as template and for the subsequent synthesis of genomic positive strand RNA from this template (Yamashita et al. 1998). , nucleoside analogs), since no RNAdependent RNA polymerase activity is present in mammalian cells. Reminiscent of HIV-1 reverse transcriptase (RT) inhibitors, two classes of HCV polymerase inhibitors, namely, nucleoside analogs and nonnucleoside inhibitors (NNI) are under development.
3 Combinatorial Chemistry . . . . . . . . . . . . . . . . . . . . . . . . 4 High-Throughput Screening for the Identification of New HCV Leads . . . . . 5 Cell-Based Assays to Predict Toxicity and Resistance Aspects . . . . . . . . . . . 6 Pharmacokinetic and Pharmacodynamic Aspects of Drug Development of Agents for the Treatment of HCV Infections . . . . . . . . . . . . . . . . . . . . . . . . 1 In Vitro Evaluation .
Antiviral strategies by Hans-Georg Kräusslich, Ralf Bartenschlager