Download e-book for kindle: Acute Promyelocytic Leukemia: Molecular Genetics, Mouse by Pier Paolo Pandolfi (Editor), Peter K. Vogt (Editor)

By Pier Paolo Pandolfi (Editor), Peter K. Vogt (Editor)

ISBN-10: 3540345922

ISBN-13: 9783540345923

ISBN-10: 3540345949

ISBN-13: 9783540345947

During the last 10 years, paintings on acute promyelocytic leukemia (APL) has develop into the paradigm of translational examine that started with the invention of a recurrent chromosomal translocation, through the id of the genes and proteins concerned, discovering their molecular features in transcriptional regulate, constructing mouse versions and culminating within the improvement  of specific remedy.

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Additional info for Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy (Current Topics in Microbiology and Immunology 313)

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Nature 391:811–814 48. Reference deleted in proof 49. Lin W, Lai CH, Tang CJ, Huang CJ, Tang TK (1999) Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP. Biochem Biophys Res Commun 264:789–795 50. Long JJ, Leresche A, Kriwacki RW, Gottesfeld JM (1998) Repression of TFIIH transcriptional activity and TFIIH-associated cdk7 kinase activity at mitosis. Mol Cell Biol 18:1467–1476 51. Look AT (1997) Oncogenic transcription factors in the human acute leukemias.

The less common splice variants AS-II, AS-III, and AS-IV have a restricted pattern of tissue-specific expression. These variants maintain the open reading frame, but encode an N-terminally truncated PLZF protein [81]. The PLZF protein is a DNA-binding zinc finger transcription factor of 673 amino acids that generally acts as a transcriptional repressor [8]. The Nterminal 118 amino acids constitute the PLZF BTB (broad-complex, tramtrack, bric a brac) domain, also known as a POZ (pox virus and zinc finger) domain, which is essential for transcriptional repression [56].

This effect of PLZF might be relevant to APL. Loss of one allele of PLZF might lead to deregulation of the stem cell; a decision in favor of proliferation may be made rather than quiescence. In this regard we note that while PLZF is a growth suppressor, the RARα-PLZF oncoprotein, which can bind to many of the same DNA-binding sites of wildtype PLZF, activates genes that PLZF represses and induces a myeloproliferative disease in mice. 42 M. J. McConnell · J. D. Licht Summary The study of the t(11;17)-associated forms of APL and the PLZF protein has served as a paradigm for the role that aberrant transcriptional repression plays in hematological malignancy.

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Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy (Current Topics in Microbiology and Immunology 313) by Pier Paolo Pandolfi (Editor), Peter K. Vogt (Editor)


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